Understanding how bacterial infections affect the blood-brain barrier in meningitis
Modulation of Blood-Brain Barrier Defense and Dysfunction during Bacterial Meningitis
This study is looking at how bacterial meningitis affects the protective barrier around the brain, to understand why some people get really sick while others don’t, with the hope of finding better ways to keep the brain safe during infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10741805 on NIH RePORTER |
What this research studies
This research investigates how bacterial meningitis disrupts the blood-brain barrier (BBB), which is crucial for protecting the brain. The study aims to identify the molecular mechanisms involved in this disruption, particularly focusing on the interactions between bacterial pathogens and the BBB. By examining how these interactions lead to changes in the endothelial cells that form the barrier, the research seeks to uncover why some patients experience severe neurological outcomes while others do not. This could lead to new therapeutic strategies to protect the brain during bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with bacterial meningitis, particularly those experiencing severe symptoms or complications.
Not a fit: Patients with viral meningitis or other non-bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that protect the brain from damage during bacterial meningitis.
How similar studies have performed: Previous research has shown promising results in understanding the blood-brain barrier's role in other infections, suggesting potential for success in this area as well.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Doran, Kelly S — University of Colorado Denver
- Study coordinator: Doran, Kelly S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.