Understanding how bacteria sense surfaces to form infections
Identifying the mechanisms of mechanosensing by the bacterial flagellar motor
This study is looking at how bacteria use their tiny tails to feel surfaces, which helps them stick together and cause infections, and by understanding this process better, we hope to find new ways to stop these infections from happening.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10979167 on NIH RePORTER |
What this research studies
This research investigates how bacteria use their flagellar motor to sense surfaces, which is crucial for their ability to form biofilms and cause infections. By employing advanced biophysical techniques, the study aims to uncover the mechanisms behind this surface sensing and how it influences bacterial behavior. The research will focus on identifying the components involved in the mechanosensing pathway and how these signals are transmitted to promote biofilm formation. This knowledge could lead to new strategies for preventing bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of bacterial infections, particularly those with conditions that promote biofilm-related complications.
Not a fit: Patients with viral infections or those not affected by bacterial biofilms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for preventing and treating bacterial infections by targeting the mechanisms of biofilm formation.
How similar studies have performed: Previous research has shown promising results in understanding bacterial behavior and biofilm formation, indicating that this approach has potential for success.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Wadhwa, Navish — Arizona State University-Tempe Campus
- Study coordinator: Wadhwa, Navish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.