Understanding how bacteria interact with human cellular signaling
Exploiting bacterial effector proteins to study human ubiquitin signaling
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11086691
This study is looking at how certain bacteria use special proteins to change the way our cells communicate, which could help us understand diseases better and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11086691 on ClinicalTrials.gov |
What this research studies
This research investigates how certain bacteria use specialized proteins to manipulate human cellular signaling pathways, specifically focusing on the ubiquitin signaling system. By examining the interactions between these bacterial effector proteins and human cells, the research aims to uncover new insights into how ubiquitin signaling is regulated and its implications for various diseases. The approach combines structural and biochemical techniques to identify and characterize these interactions, potentially revealing novel therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bacterial infections or diseases linked to dysfunctional ubiquitin signaling.
Not a fit: Patients with non-bacterial infections or those whose conditions are unrelated to ubiquitin signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by bacterial infections and other conditions related to ubiquitin signaling dysregulation.
How similar studies have performed: Other research has shown promise in understanding bacterial interactions with host cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRUNEDA, JONATHAN N — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: PRUNEDA, JONATHAN N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections