Understanding how bacteria form biofilms in the intestines and their impact on diseases
Determinants of bacterial biofilm formation at the intestinal mucosal interface and their roles in pathogen exclusion
['FUNDING_CAREER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10806983
This study is looking at how certain bacteria form sticky layers in the gut and how this might be linked to conditions like colorectal cancer and inflammatory bowel disease, with the hope of finding new ways to help manage these illnesses.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10806983 on ClinicalTrials.gov |
What this research studies
This research investigates how bacterial biofilms form at the intestinal mucosal surface and their potential role in diseases like colorectal cancer and inflammatory bowel disease. The study aims to explore the mechanisms behind biofilm formation, particularly focusing on a specific E. coli gene that influences this process. By using animal models, the researchers will analyze how these biofilms affect bacterial colonization and disease progression. The findings could provide insights into new therapeutic strategies for managing intestinal diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from intestinal diseases such as inflammatory bowel disease or colorectal cancer.
Not a fit: Patients with non-bacterial related intestinal disorders or those not experiencing any intestinal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or manage intestinal diseases linked to bacterial infections.
How similar studies have performed: Previous research has shown that understanding bacterial biofilms can lead to significant advancements in treating infections, suggesting this approach has potential for success.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NI, JOSEPHINE — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: NI, JOSEPHINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections