Understanding how bacteria control protein synthesis quality
Official title: Structural bases for protein synthesis quality control
Funded at University of Texas Med Br Galveston · NIH-11090094 · Data updated 2026-11-12
This study looks at how tiny parts of bacteria help make proteins correctly, which is important for their survival, and it aims to find new ways to create antibiotics that can better fight off tough bacterial infections, ultimately helping patients get better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $375,420 |
| NIH project number | 1R35GM158272-01 |
| Project ID | NIH-11090094 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from bacterial infections, particularly those caused by antibiotic-resistant strains.
✕Less likely to help
Patients with viral infections or those who do not have bacterial infections may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which bacterial ribosomes ensure the accuracy of protein synthesis, which is crucial for gene expression. It focuses on the role of specific translation factors that help monitor and correct errors during this process. By exploring how these factors interact with ribosomes, the research aims to uncover new strategies for developing antibiotics that can effectively combat antibiotic-resistant bacteria. Patients may benefit from improved treatments for bacterial infections as a result of this work.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against resistant bacterial infections.
How similar studies have gone: Other research has shown promise in understanding ribosomal function and its implications for antibiotic development, indicating that this approach could yield significant advancements.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Gagnon, Matthieu — University of Texas Med Br Galveston
- Study coordinator: Gagnon, Matthieu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.