Understanding how bacteria communicate in chronic lung infections
Quinolone and acyl-homoserine lactone quorum sensing in chronic P. aeruginosa infections
This research explores how the bacteria Pseudomonas aeruginosa communicate to cause long-lasting infections, especially in people with cystic fibrosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11127693 on NIH RePORTER |
What this research studies
Pseudomonas aeruginosa is a common germ that can cause serious, long-term infections in people, particularly those with cystic fibrosis. These bacteria use a special communication system, called quorum sensing, to coordinate their actions and make infections harder to treat. We are learning how this communication system changes in chronic infections, making the bacteria more harmful. By understanding these changes, we hope to find new ways to disrupt their communication and fight these persistent infections.
Who could benefit from this research
Good fit: This foundational research is most relevant to patients experiencing chronic Pseudomonas aeruginosa infections, such as those with cystic fibrosis.
Not a fit: Patients without chronic Pseudomonas aeruginosa infections or those with acute, easily treatable infections may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target bacterial communication, making chronic Pseudomonas aeruginosa infections easier to manage or prevent.
How similar studies have performed: This project builds upon previous observations by the researchers and others, suggesting a growing understanding of bacterial communication in chronic infections.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Dandekar, Ajai — University of Washington
- Study coordinator: Dandekar, Ajai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.