Understanding how bacteria build their protective outer layer
Official title: Characterizing the regulation of cell envelope biosynthesis in Pseudomonas aeruginosa
Funded at University of Georgia · NIH-11020365 · Data updated 2026-11-12
This study looks at how a tough bacteria called Pseudomonas aeruginosa makes its protective outer layer, which helps it survive against antibiotics, and by understanding this process better, researchers hope to find new ways to fight infections caused by this bacteria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | January 6, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $361,297 |
| NIH project number | 1R35GM157138-01 |
| Project ID | NIH-11020365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria, particularly those involving Pseudomonas aeruginosa.
✕Less likely to help
Patients with infections caused by non-resistant strains of bacteria or those not infected with Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research investigates the processes that regulate the biosynthesis of the cell envelope in Pseudomonas aeruginosa, a type of bacteria known for its resistance to antibiotics. By examining the pathways that produce essential components of the cell envelope, the research aims to uncover how these processes are controlled to ensure the bacteria's survival and growth. The study employs biochemical techniques to analyze the interactions and regulations of various biosynthetic pathways, which could lead to new strategies for combating antibiotic resistance.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively target and disrupt the protective layers of antibiotic-resistant bacteria.
How similar studies have gone: Other research has shown promise in targeting bacterial cell envelope biosynthesis as a novel approach to overcoming antibiotic resistance.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Hummels, Katherine Ruth — University of Georgia
- Study coordinator: Hummels, Katherine Ruth
Related research
Other NIH-funded projects on the same topics.
-
BRD4 and NIPBL work together to control facial bone development
A study in mice and cell models will explore how BRD4 and NIPBL work together to control how genes are turned on in facial development, which could clarify causes of craniofacial disorders.
-
Sulfated glycosaminoglycan hydrogels to protect brain volume after traumatic injury
A new implantable gel made from specially sulfated sugars may help prevent brain shrinkage and improve function after a serious brain injury.
-
Understanding how Kaposi’s sarcoma virus switches on late genes during infection
Scientists are studying how the virus causing Kaposi’s sarcoma turns on late genes when its DNA copies itself, which could reveal new ways to treat cancer in people with AIDS.
-
Understanding how cells control signals and adhesion with the secretory pathway
A funded NIH project looks at how the cell’s secretory system shapes signals, receptors, and attachment to the outside of the cell, which can influence many human diseases.
-
AI-powered math and machine learning for bioscience and drug discovery
A broad NIH grant supports using advanced math and AI to better predict viral variants and aid drug discovery, with the goal of helping patients by accelerating pandemic response.
-
AI-driven platform to predict vaccine-escape variants and design mutation-proof antibodies
An AI-powered approach aims to anticipate SARS-CoV-2 variants that may dodge vaccines and to create antibodies that stay effective.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.