Understanding how bacteria become resistant to multiple antibiotics
Evolution and consequences of multidrug resistant ribosome
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10902117
This study is looking at how a tiny change in bacteria helps them resist antibiotics, which could lead to new ways to fight infections that are hard to treat.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10902117 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific modifications in bacterial ribosomes that contribute to antibiotic resistance. By focusing on a particular adenine modification in bacterial RNA, the study aims to uncover how this change allows bacteria to survive despite treatment with critical antibiotics. The approach includes analyzing the genetic and biochemical pathways involved in this resistance, which could lead to new strategies for overcoming antibiotic resistance in bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that effectively combat multidrug-resistant bacterial infections.
How similar studies have performed: Other research has shown promising results in understanding antibiotic resistance mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAP, M.-N. FRANCES — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: YAP, M.-N. FRANCES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections