Understanding how bacteria adapt and evolve in different environments
Official title: Deciphering the processes of adaptation and exaptation driving the evolution of opportunism in bacteria
Funded at North Carolina State University Raleigh · NIH-11057650 · Data updated 2026-11-12
This study is looking at how bacteria change and adapt, which can help us understand why some bacteria are good for us while others can make us sick, especially in hospitals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | April 13, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $319,200 |
| NIH project number | 5R01GM145747-04 |
| Project ID | NIH-11057650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of hospital-acquired infections, particularly those caused by opportunistic bacteria.
✕Less likely to help
Patients who do not have any bacterial infections or are not at risk of such infections may not benefit from this research.
What this research studies
This research investigates the complex evolution of bacteria, focusing on how they adapt to various lifestyles, including being beneficial or harmful to humans. By integrating multiple approaches such as computer simulations, laboratory experiments, and studies in living organisms, the research aims to uncover the factors that drive bacterial evolution. This understanding is crucial for addressing the challenges posed by opportunistic bacteria, which can cause serious infections, especially in hospital settings.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for preventing and treating infections caused by multidrug-resistant bacteria.
How similar studies have gone: Other research has shown success in understanding bacterial evolution through genomic studies, but this integrated approach is relatively novel.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Raymann, Kasie Tyler — North Carolina State University Raleigh
- Study coordinator: Raymann, Kasie Tyler
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.