Understanding how B cells respond to different signals in autoimmune diseases
Official title: Metabolic enforcement of selection in anti-DNA B cells vs. antigen-specific B cells
Funded at University of Florida · NIH-10953874 · Data updated 2026-11-12
This study is looking at how a type of immune cell called B cells decides what to attack and what to ignore, especially in autoimmune diseases where the body mistakenly harms itself, and it hopes to find ways to help manage these conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 16, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $530,791 |
| NIH project number | 1R01AI185774-01 |
| Project ID | NIH-10953874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune diseases, particularly those involving B cell dysfunction.
✕Less likely to help
Patients with non-autoimmune conditions or those without B cell involvement may not benefit from this research.
What this research studies
This research investigates the mechanisms by which B cells, a type of immune cell, differentiate between harmful and harmless signals. It focuses on how certain proteins influence the survival and death of B cells, particularly in the context of autoimmune diseases where the body mistakenly attacks its own tissues. By examining the role of specific ligands and metabolic changes in B cells, the study aims to uncover why some B cells become autoreactive while others do not. This could lead to new insights into how to better manage autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases by enhancing our understanding of B cell behavior.
How similar studies have gone: Previous research has shown promising results in understanding B cell selection processes, but this specific approach is relatively novel.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Moser, Emily K. — University of Florida
- Study coordinator: Moser, Emily K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.