Understanding how B cells recognize antigens better
Official title: Regulation of B cell receptor avidity to organize antigen recognition
Funded at Harvard Medical School · NIH-10993377 · Data updated 2026-11-12
This study is looking at how the number of spots on B cell receptors helps them recognize germs better, which could help us understand how our immune system gets stronger and picks the best antibodies to fight infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $43,456 |
| NIH project number | 1F31AI186217-01 |
| Project ID | NIH-10993377 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with immune system disorders or those interested in understanding their immune responses better.
✕Less likely to help
Patients with stable immune conditions who do not require further investigation into their B cell function may not benefit from this research.
What this research studies
This research investigates how the number of binding sites on B cell receptors affects their ability to recognize antigens. By using a specially designed tool to measure these binding sites, the study aims to understand how B cells develop and optimize their response to infections. The approach focuses on the developmental stages of B cells, examining how their receptor binding capabilities change and improve over time. This could lead to insights into how the immune system selects the most effective antibodies during an immune response.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, potentially leading to improved vaccines and therapies for various diseases.
How similar studies have gone: Previous research has shown that understanding B cell receptor dynamics can lead to significant advancements in immunology, suggesting this approach has the potential for success.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Rosado, Victoria Celine — Harvard Medical School
- Study coordinator: Rosado, Victoria Celine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.