Understanding how autoantibodies form and function in COVID-19
Official title: Elucidating the immunology of autoantibody formation and function in COVID-19
Funded at Stanford University · NIH-10886042 · Data updated 2026-11-12
This study is looking at how certain antibodies in people with COVID-19 might cause inflammation and affect their immune system, helping us understand why some patients get sicker than others.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 11, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $732,313 |
| NIH project number | 5R01AI175771-02 |
| Project ID | NIH-10886042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with COVID-19, particularly those experiencing severe symptoms or autoimmune manifestations.
✕Less likely to help
Patients who have not been infected with COVID-19 or those with pre-existing autoimmune conditions unrelated to COVID-19 may not benefit from this research.
What this research studies
This research investigates the formation and role of autoantibodies in patients with COVID-19, focusing on how these antibodies may contribute to inflammation and autoimmune responses during the infection. By analyzing a large collection of patient samples and clinical data, the study aims to uncover the mechanisms behind B cell tolerance and the generation of autoantibodies. The research will explore the relationship between these autoantibodies and the severity of COVID-19, potentially revealing new insights into immune responses in infected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of autoimmune responses in COVID-19 patients.
How similar studies have gone: While the investigation of autoantibodies in COVID-19 is a relatively novel approach, there have been successful studies exploring immune responses in other viral infections.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Rogers, Angela J — Stanford University
- Study coordinator: Rogers, Angela J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.