Understanding how autoantibodies form and function in COVID-19
Elucidating the immunology of autoantibody formation and function in COVID-19
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10886042
This study is looking at how certain antibodies in people with COVID-19 might cause inflammation and affect their immune system, helping us understand why some patients get sicker than others.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10886042 on ClinicalTrials.gov |
What this research studies
This research investigates the formation and role of autoantibodies in patients with COVID-19, focusing on how these antibodies may contribute to inflammation and autoimmune responses during the infection. By analyzing a large collection of patient samples and clinical data, the study aims to uncover the mechanisms behind B cell tolerance and the generation of autoantibodies. The research will explore the relationship between these autoantibodies and the severity of COVID-19, potentially revealing new insights into immune responses in infected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with COVID-19, particularly those experiencing severe symptoms or autoimmune manifestations.
Not a fit: Patients who have not been infected with COVID-19 or those with pre-existing autoimmune conditions unrelated to COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of autoimmune responses in COVID-19 patients.
How similar studies have performed: While the investigation of autoantibodies in COVID-19 is a relatively novel approach, there have been successful studies exploring immune responses in other viral infections.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROGERS, ANGELA J — STANFORD UNIVERSITY
- Study coordinator: ROGERS, ANGELA J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome