Understanding how autoantibodies develop in lupus over time
Evolution of autoreactive GC and epitope spreading in lupus
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10929546
This study is looking at how certain immune cells in people with lupus change over time and start attacking more parts of the body, which could help us understand how the disease gets worse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10929546 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the development of autoantibodies in systemic lupus erythematosus (SLE), an autoimmune disease. By using a novel mouse model, researchers will track how specific B cells evolve and contribute to the disease over time. The study focuses on the phenomenon known as epitope spreading, where the immune system begins to attack new targets beyond the initial self-antigen. Through this approach, the research aims to uncover the dynamics of self-reactive B cells and their role in disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus who may be experiencing the progression of their disease.
Not a fit: Patients with other autoimmune diseases or those not diagnosed with lupus may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lupus by targeting the mechanisms of autoantibody development.
How similar studies have performed: Previous research has shown promising results in understanding autoimmunity through similar approaches, indicating potential for success in this study.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARROLL, MICHAEL CRAIG — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: CARROLL, MICHAEL CRAIG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases