Understanding how arteriovenous fistulas develop problems after creation
BCCMA: Cardiovascular Remodeling following Arteriovenous Fistula Creation: Autophagy Contributes to Adverse Arteriovenous Fistula Remodeling
['FUNDING_OTHER'] · BIRMINGHAM VA MEDICAL CENTER · NIH-10925548
This study is looking into why some arteriovenous fistulas (AVFs), which are important for patients on dialysis, don’t develop as they should, and it hopes to find ways to help more of them work better for those who need them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BIRMINGHAM VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10925548 on ClinicalTrials.gov |
What this research studies
This research investigates the reasons why arteriovenous fistulas (AVFs), which are crucial for hemodialysis in patients with end-stage kidney disease, often fail to mature properly. The study aims to uncover the biological mechanisms behind AVF maturation failure, focusing on factors such as aging and specific cellular processes. By examining these mechanisms, the research seeks to develop new therapies that could improve the success rates of AVF maturation, ultimately benefiting patients who rely on these procedures for dialysis.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans with end-stage kidney disease who require hemodialysis and are undergoing arteriovenous fistula creation.
Not a fit: Patients who do not require hemodialysis or who have alternative vascular access methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients requiring hemodialysis, enhancing the success rates of arteriovenous fistulas.
How similar studies have performed: Other research has shown promise in understanding vascular access issues in hemodialysis, but this specific approach focusing on AVF maturation mechanisms is relatively novel.
Where this research is happening
BIRMINGHAM, UNITED STATES
- BIRMINGHAM VA MEDICAL CENTER — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, TIMMY C — BIRMINGHAM VA MEDICAL CENTER
- Study coordinator: LEE, TIMMY C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease