Understanding how arsine gas causes kidney injury
Defining molecular target of arsine gas-induced acute kidney injury and associated morbidity
['FUNDING_R21'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11096628
This study is looking at how arsine gas can harm the kidneys by breaking down red blood cells, and it's aimed at helping people who might be exposed to this dangerous chemical by finding ways to prevent and treat kidney damage.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11096628 on ClinicalTrials.gov |
What this research studies
This research investigates the harmful effects of arsine gas, a toxic chemical that can lead to acute kidney injury (AKI) through the destruction of red blood cells. By studying animal models, the researchers aim to uncover the molecular mechanisms behind this injury, focusing on how hemoglobin and heme released into the bloodstream can damage kidney cells. The study will utilize biomarkers to track kidney damage and assess the severity of injury caused by arsine exposure. This work is crucial for developing potential treatments and preventive measures for those exposed to this hazardous substance.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been exposed to arsine gas, particularly in occupational settings or during accidental releases.
Not a fit: Patients who have not been exposed to arsine gas or who have chronic kidney conditions unrelated to acute injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from acute kidney injury due to chemical exposure.
How similar studies have performed: While the specific focus on arsine gas is novel, similar studies on chemical-induced kidney injury have shown promising results in understanding the underlying mechanisms.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SRIVASTAVA, RITESH KUMAR — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: SRIVASTAVA, RITESH KUMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute kidney injury