Understanding how arsine gas causes kidney injury
Official title: Defining molecular target of arsine gas-induced acute kidney injury and associated morbidity
Funded at University of Alabama at Birmingham · NIH-11096628 · Data updated 2026-11-12
This study is looking at how arsine gas can harm the kidneys by breaking down red blood cells, and it's aimed at helping people who might be exposed to this dangerous chemical by finding ways to prevent and treat kidney damage.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | June 20, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $222,750 |
| NIH project number | 1R21ES036166-01A1 |
| Project ID | NIH-11096628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to arsine gas, particularly in occupational settings or during accidental releases.
✕Less likely to help
Patients who have not been exposed to arsine gas or who have chronic kidney conditions unrelated to acute injury may not benefit from this research.
What this research studies
This research investigates the harmful effects of arsine gas, a toxic chemical that can lead to acute kidney injury (AKI) through the destruction of red blood cells. By studying animal models, the researchers aim to uncover the molecular mechanisms behind this injury, focusing on how hemoglobin and heme released into the bloodstream can damage kidney cells. The study will utilize biomarkers to track kidney damage and assess the severity of injury caused by arsine exposure. This work is crucial for developing potential treatments and preventive measures for those exposed to this hazardous substance.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from acute kidney injury due to chemical exposure.
How similar studies have gone: While the specific focus on arsine gas is novel, similar studies on chemical-induced kidney injury have shown promising results in understanding the underlying mechanisms.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Srivastava, Ritesh Kumar — University of Alabama at Birmingham
- Study coordinator: Srivastava, Ritesh Kumar
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.