Understanding how arsenic and manganese affect metabolism
Interdisciplinary approaches for understanding the metabolic effects of arsenic and manganese
This study is looking at how exposure to arsenic and manganese affects our metabolism and could lead to health issues like cancer, and it's for anyone interested in understanding their risks and how folate supplements might help reduce those risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10470810 on NIH RePORTER |
What this research studies
This research investigates the metabolic effects of arsenic and manganese exposure, which are significant health concerns for millions globally. By analyzing data and biological samples from a previous clinical trial, the study aims to uncover the mechanisms through which these substances contribute to chronic diseases, including cancer. The approach includes innovative metabolomics techniques to identify individuals at risk before disease onset, focusing on how folate supplementation may enhance arsenic methylation and reduce toxicity. The ultimate goal is to develop strategies for better risk identification and management.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals exposed to arsenic and manganese, particularly those living in areas with contaminated drinking water.
Not a fit: Patients who are not exposed to arsenic or manganese, or who do not have chronic diseases related to these exposures, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying individuals at risk of arsenic and manganese-related health issues, potentially reducing the incidence of chronic diseases.
How similar studies have performed: Previous research has shown promising results in understanding arsenic metabolism and the effects of folate supplementation, indicating that this approach has potential for further success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Gamble, Mary — Columbia University Health Sciences
- Study coordinator: Gamble, Mary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.