Understanding how ARID1A mutations affect gastric cancer in Latino populations
Official title: The role of ARID1A mutations in Latino gastric cancer biology and disparities
Funded at University of California at Davis · NIH-11064500 · Data updated 2026-11-12
This study is looking at how changes in the ARID1A gene affect stomach cancer, especially in Latino patients, and it aims to create new models to better understand the disease and test current treatments to help improve care for diverse groups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $88,437 |
| NIH project number | 3U54CA283766-02S1 |
| Project ID | NIH-11064500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Latino individuals diagnosed with gastric cancer, particularly those with ARID1A mutations.
✕Less likely to help
Patients who do not have gastric cancer or those outside the Latino demographic may not benefit from this research.
What this research studies
This research focuses on the role of ARID1A gene mutations in the biology of gastric cancer, particularly within Latino populations. By establishing and characterizing new patient-derived xenografts (PDXs), the study aims to create preclinical models that reflect the diversity of cancer patients. These models will be used to explore the mechanisms of cancer development and to test existing FDA-approved therapies, ultimately aiming to improve treatment outcomes for underrepresented groups. The research involves collaboration among several leading cancer centers to ensure a comprehensive approach to cancer health disparities.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for Latino patients with gastric cancer.
How similar studies have gone: Previous research has shown promise in using patient-derived xenografts to study cancer biology and test therapies, indicating a strong potential for success in this approach.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Carvajal Carmona, Luis Guillermo — University of California at Davis
- Study coordinator: Carvajal Carmona, Luis Guillermo
Related research
Other NIH-funded projects on the same topics.
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Advancing gastric cancer care for Latinos through patient-derived tumor models
Aimed at Latinos with gastric cancer, this project uses patient-derived tumor models to study how cancer biology and treatments work in real tumors.
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Circulating metabolites as early warning signs for gastric cancer
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Understanding why racial differences exist in stomach cancer in the US
This grant studies why some racial groups in the US have higher stomach cancer rates, focusing on how Helicobacter pylori infection and host responses contribute to these differences.
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Understanding how gastric cancer starts and grows in the stomach
Researchers at Columbia are studying how two main types of stomach cancer begin and progress, using new mouse models and advanced single-cell and spatial analysis to map where cancer cells come from and how they change.
-
Gastric cancer prevention and screening modeled to guide US care
A nationwide modeling project uses AI and advanced simulations to help decide who should be tested and treated for stomach cancer prevention and screening in the United States.
-
Improved fibrin-targeted radiopharmaceutical for gastric cancer
A new radiopharmaceutical targets fibrin in gastric cancer to help treat advanced disease with potentially fewer side effects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.