Understanding how arginine methylation affects cell signaling
Official title: A Functional Analysis of Arginine Methylation
Funded at University of Tx Md Anderson Can Ctr · NIH-10842017 · Data updated 2026-11-12
This study is looking at how a small change in proteins, called arginine methylation, affects how cells work and respond to things like DNA damage, and it's for anyone interested in understanding more about how our cells communicate and function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $405,000 |
| NIH project number | 1R35GM153387-01 |
| Project ID | NIH-10842017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to DNA damage or signaling pathway disruptions.
✕Less likely to help
Patients with conditions unrelated to arginine methylation or those not experiencing issues with DNA damage may not benefit from this research.
What this research studies
This research investigates the biological roles of arginine methylation, a common modification that affects protein function and communication within cells. The team will explore how this modification is recognized by specific proteins and its impact on cellular processes, including responses to DNA damage. By using advanced techniques such as proteomic screens and mouse models, the researchers aim to fill knowledge gaps regarding the effects of arginine methylation and its role in signaling pathways.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular communication and potential therapeutic targets for diseases related to DNA damage and signaling dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the roles of other post-translational modifications, suggesting potential for success in this area as well.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Bedford, Mark T. — University of Tx Md Anderson Can Ctr
- Study coordinator: Bedford, Mark T.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.