Understanding how antibodies affect brain signaling in autoimmune encephalitis
Impact of human anti-NMDA receptor antibodies on glutamate receptor signaling, calcium mobilization, and hippocampal neuronal circuits in autoimmune encephalitis
This study is looking at how certain antibodies in the body can affect brain function in people with autoimmune encephalitis, with the hope of finding new ways to help improve treatments for those living with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10811827 on NIH RePORTER |
What this research studies
This research investigates the role of human antibodies that bind to neuronal cell surface proteins in autoimmune encephalitis, a condition that affects brain function. By using advanced techniques such as proteomics and live cell microscopy, the study aims to uncover how these antibodies disrupt signaling pathways and calcium mobilization in the brain. The ultimate goal is to identify new therapeutic targets that could improve treatment options for patients suffering from this neurological disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune encephalitis who have detectable anti-NMDA receptor antibodies.
Not a fit: Patients with other neurological disorders not related to autoimmune encephalitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with autoimmune encephalitis.
How similar studies have performed: Previous research has shown promise in understanding the role of antibodies in neurological diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Benavides, David Roger — University of Maryland Baltimore
- Study coordinator: Benavides, David Roger
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.