Understanding how AMPA receptors work in the brain
AMPAR Function in Synaptic and Extrasynaptic Membranes
This study is looking at how certain brain receptors help nerve cells talk to each other, especially in the part of the brain that controls movement and balance, to see how different types of these receptors might change how we respond to feelings like fear.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10640949 on NIH RePORTER |
What this research studies
This research investigates the role of AMPA receptors in the brain, focusing on how they facilitate communication between neurons. It examines the differences between two types of AMPA receptors: those that allow calcium to enter the cell and those that do not. By studying these receptors in a specific part of the brain known as the cerebellum, the research aims to uncover how changes in receptor types can affect brain function, particularly in response to experiences like fear. The approach involves advanced biophysical techniques to analyze receptor behavior and their implications for brain plasticity.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who may be experiencing neurological conditions or disorders related to synaptic transmission.
Not a fit: Patients with non-neurological conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain disorders and potential therapeutic targets for conditions related to synaptic dysfunction.
How similar studies have performed: Previous research has shown success in understanding AMPA receptor functions, indicating that this approach is built on established scientific principles.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Wadiche, Jacques — University of Alabama at Birmingham
- Study coordinator: Wadiche, Jacques
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.