Understanding how alcohol affects the brain's immune system and decision-making.
Official title: Neuroimmune mechanisms of adult chronic ethanol consumption
Funded at State University of Ny,binghamton · NIH-10727281 · Data updated 2026-11-12
This study is looking at how long-term drinking affects the brain's immune system and how that might impact decision-making and emotions, specifically for people dealing with alcohol use disorder, to find better treatment options that are easier on the body.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | September 12, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $404,508 |
| NIH project number | 1R21AA031101-01 |
| Project ID | NIH-10727281 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are struggling with alcohol use disorder.
✕Less likely to help
Patients who do not have alcohol use disorder or are under the age of 21 may not benefit from this research.
What this research studies
This research investigates the effects of chronic alcohol consumption on the brain's immune system and its role in decision-making and emotional processing. It focuses on individuals with alcohol use disorder (AUD), who often experience cognitive challenges that hinder their treatment and recovery. By examining the neuroimmune mechanisms, particularly the role of the cytokine interleukin-1β, the study aims to identify new treatment strategies that minimize side effects. The research will analyze how chronic ethanol exposure alters immune signaling in the brain, potentially leading to better therapeutic options for those struggling with AUD.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for individuals with alcohol use disorder, enhancing their cognitive function and recovery outcomes.
How similar studies have gone: Previous research has shown promising results in targeting neuroimmune mechanisms for treating alcohol use disorder, suggesting that this approach may be effective.
Where this research is happening
-
State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Varodayan, Florence Prabha — State University of Ny,binghamton
- Study coordinator: Varodayan, Florence Prabha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.