Understanding how Aiolos affects immune cells in the gut
Impact of Aiolos on intestinal intraepithelial lymphocytes
This study is looking at how a protein called Aiolos affects certain immune cells in the gut that play a role in inflammatory bowel disease (IBD), with the hope of finding new ways to help patients who struggle with current treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10791748 on NIH RePORTER |
What this research studies
This research investigates the role of Aiolos, a transcription factor, in regulating intestinal intraepithelial lymphocytes (IELs), which are immune cells located in the gut. The study aims to uncover how Aiolos influences the activation of these cells, particularly in the context of inflammatory bowel disease (IBD). By utilizing advanced techniques like ATAC sequencing, the research will explore the chromatin remodeling processes that Aiolos mediates, potentially leading to new therapeutic strategies for patients with IBD. The findings could provide insights into why some patients respond poorly to existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those experiencing inadequate responses to current therapies.
Not a fit: Patients without inflammatory bowel disease or those whose condition is unrelated to immune cell activation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from inflammatory bowel disease, improving their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding immune cell regulation in other autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Yomogida, Kentaro — University of Colorado Denver
- Study coordinator: Yomogida, Kentaro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.