Understanding how aging affects stem cells that help repair bones
Official title: Dissecting the aging skeletal stem cell niche
Funded at New York University School of Medicine · NIH-11140967 · Data updated 2026-11-12
This study looks at how getting older affects the special cells that help keep our bones healthy and heal after injuries, especially focusing on how inflammation might make these cells less effective, with the goal of finding new ways to improve bone health and healing in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $644,000 |
| NIH project number | 5R01AG086058-02 |
| Project ID | NIH-11140967 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older, particularly those experiencing age-related bone health issues.
✕Less likely to help
Patients who are younger than 21 or do not have age-related bone health concerns may not benefit from this research.
What this research studies
This research investigates how aging impacts the function of skeletal stem cells, which are crucial for maintaining and repairing bone tissue. The study focuses on the role of inflammation in the decline of these stem cells' abilities as people age. By examining the molecular mechanisms behind inflammation and how it affects stem cell function, the researchers aim to identify potential therapies that could enhance bone health and improve fracture healing in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone health and reduce fracture risks in elderly patients.
How similar studies have gone: Other research has shown promising results in understanding the role of inflammation in stem cell function, suggesting that this approach could yield significant insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Leucht, Philipp — New York University School of Medicine
- Study coordinator: Leucht, Philipp
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.