Understanding how aging affects senescent cells in human tissues
Biological Analysis Core
This study is looking at how old cells that don't work properly build up in our bodies as we age and how they might affect our health, so we can better understand their role in diseases and find new ways to help people stay healthy as they get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10899786 on NIH RePORTER |
What this research studies
This research investigates the accumulation of senescent cells (SnCs) as people age and their impact on health. It aims to identify when and where these cells arise in various human tissues, including adipose, skeletal muscle, liver, and ovarian tissues. By using advanced methods for analyzing these cells, the study will create detailed atlases that map SnC distribution and characteristics across different ages. This information will help in understanding the role of SnCs in health and disease, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy individuals across a range of ages who can provide tissue samples for analysis.
Not a fit: Patients with significant health issues or those who are not able to provide tissue samples may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of age-related diseases by targeting senescent cells.
How similar studies have performed: Previous research has shown promise in understanding senescent cells, but this approach aims to provide a more comprehensive analysis that has not been extensively tested.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Robbins, Paul D. — University of Minnesota
- Study coordinator: Robbins, Paul D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.