Understanding how aging affects ovarian function
Official title: Mechanotransduction mechanisms of ovarian aging
Funded at Washington University · NIH-10914737 · Data updated 2026-11-12
This study is looking at how getting older affects women's eggs and fertility, especially how the stiffness of ovarian tissue might play a role, to help find better ways to support women facing fertility challenges as they age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 30, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $141,245 |
| NIH project number | 5R00HD108424-04 |
| Project ID | NIH-10914737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing difficulties conceiving, particularly those of advanced reproductive age.
✕Less likely to help
Patients who are not experiencing fertility issues or are not of reproductive age may not benefit from this research.
What this research studies
This research investigates the mechanisms by which aging impacts the female reproductive system, particularly focusing on the quality and quantity of oocytes. It examines how physical properties of the ovarian tissue, such as stiffness, influence cell behavior and contribute to fertility issues. By utilizing advanced techniques to measure the biomechanical properties of the ovary, the study aims to uncover the relationship between the ovarian microenvironment and reproductive aging. The findings could lead to new insights into fertility preservation and treatment options for women experiencing age-related fertility decline.
Why it matters
Potential benefit: If successful, this research could provide new strategies to improve fertility in aging women.
How similar studies have gone: Previous research has shown promising results in understanding the impact of the ovarian microenvironment on fertility, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Amargant I Riera, Farners — Washington University
- Study coordinator: Amargant I Riera, Farners
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.