Understanding how aging affects lung healing in severe respiratory conditions
Official title: Negative regulators of endothelial regeneration in aging lungs and ARDS
Funded at Lurie Children's Hospital of Chicago · NIH-11075127 · Data updated 2026-11-12
This study is looking at why older adults with Acute Respiratory Distress Syndrome (ARDS) have a harder time healing their lungs, especially after infections, and it hopes to find new ways to help them recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 1, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $601,820 |
| NIH project number | 5R01HL164014-04 |
| Project ID | NIH-11075127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have experienced ARDS, particularly those with a history of sepsis.
✕Less likely to help
Patients who are younger and do not have a history of ARDS or sepsis may not benefit from this research.
What this research studies
This research investigates the mechanisms behind impaired lung healing in older adults suffering from Acute Respiratory Distress Syndrome (ARDS), particularly following sepsis. It focuses on the role of specific proteins that regulate endothelial regeneration, which is crucial for lung recovery. By using advanced genetic techniques, the study aims to identify how aging affects these processes and explore potential therapies that could enhance lung repair in elderly patients. The ultimate goal is to develop targeted treatments that can improve outcomes for older individuals with ARDS.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve lung recovery and survival rates in elderly patients with ARDS.
How similar studies have gone: While the specific approach of targeting endothelial regeneration in aging lungs is novel, similar research has shown promise in understanding and treating ARDS in younger populations.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Zhao, You-Yang — Lurie Children's Hospital of Chicago
- Study coordinator: Zhao, You-Yang
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.