Understanding how aging affects inflammation in heart disease
Senescence dysregulates of inflammation-resolution programs in atherosclerosis
['FUNDING_R01'] · ALBANY MEDICAL COLLEGE · NIH-10631070
This study is looking at how aging affects the body's ability to calm down inflammation related to heart disease, and it's aimed at helping patients understand how this process works and what new treatments might be available to improve their heart health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBANY MEDICAL COLLEGE (nih funded) |
| Locations | 1 site (ALBANY, UNITED STATES) |
| Trial ID | NIH-10631070 on ClinicalTrials.gov |
What this research studies
This research investigates how cellular aging, specifically senescence, disrupts the body's ability to resolve inflammation in atherosclerosis, a major cause of cardiovascular disease. The study focuses on the balance between pro-resolving mediators that help reduce inflammation and pro-inflammatory factors that can worsen the condition. By exploring the mechanisms behind this imbalance, the researchers aim to identify new treatment strategies that could restore the body's natural resolution processes. Patients may benefit from insights into how aging impacts their cardiovascular health and potential new therapies targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with atherosclerotic cardiovascular disease, particularly those experiencing age-related inflammation issues.
Not a fit: Patients without atherosclerosis or those who are not experiencing significant inflammation-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve heart health by enhancing the body's ability to resolve inflammation.
How similar studies have performed: Previous research has shown that targeting inflammation can be effective in managing atherosclerosis, suggesting that this approach may yield promising results.
Where this research is happening
ALBANY, UNITED STATES
- ALBANY MEDICAL COLLEGE — ALBANY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREDMAN, GABRIELLE — ALBANY MEDICAL COLLEGE
- Study coordinator: FREDMAN, GABRIELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease, Cardiovascular Diseases, cardiovascular disorder