Understanding how aging affects blood vessel function
Official title: Identification of Molecular Features Associated with Vascular Alterations in Aging
Funded at Rutgers Biomedical and Health Sciences · NIH-11038207 · Data updated 2026-11-12
This study is looking at how our blood vessels change as we get older, which can lead to health issues, and it's for anyone interested in understanding how aging affects our vascular health and what new treatments might help.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $431,750 |
| NIH project number | 1R21AG091016-01 |
| Project ID | NIH-11038207 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing vascular-related health issues or chronic diseases associated with aging.
✕Less likely to help
Patients who are younger and do not have any vascular dysfunction or age-related diseases may not benefit from this research.
What this research studies
This research investigates the molecular changes in blood vessels that occur as people age, which can lead to various chronic diseases. By examining the behavior of endothelial cells, which line blood vessels, the team aims to identify specific markers and ligands that can help in understanding age-related vascular dysfunction. The study employs innovative techniques, including in vivo phage display, to isolate and characterize these molecular features in both young and aged mice. This approach could provide insights into how aging impacts vascular health and contribute to the development of targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related vascular diseases.
How similar studies have gone: Previous research has shown promise in identifying molecular features related to aging and vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Pasqualini, Renata — Rutgers Biomedical and Health Sciences
- Study coordinator: Pasqualini, Renata
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.