Understanding how aging affects blood vessel function
Official title: Integrative Mechanisms of Vascular Aging
Funded at University of Utah · NIH-11001233 · Data updated 2026-11-12
This study looks at how aging affects blood vessel function, especially the inner lining, and how a protective layer can impact blood flow and heart health, with the goal of finding ways to help improve blood vessel health in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | April 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $413,711 |
| NIH project number | 5R01AG077751-03 |
| Project ID | NIH-11001233 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related vascular changes.
✕Less likely to help
Patients who are younger and do not exhibit any age-related vascular issues may not benefit from this research.
What this research studies
This research investigates the changes in blood vessel function that occur as people age, focusing on the endothelium, which is the inner lining of blood vessels. It examines how the deterioration of a protective layer called the glycocalyx impacts blood flow and overall cardiovascular health. By studying these mechanisms, the research aims to identify potential targets for interventions that could improve vascular function in older adults. Patients may be involved in assessments that help understand these age-related changes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cardiovascular health in older adults.
How similar studies have gone: Previous research has shown promising results in understanding vascular aging, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Donato, Anthony John — University of Utah
- Study coordinator: Donato, Anthony John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.