Understanding how ADAR1 affects immune responses to RNA
Regulatory and Mechanistic Understanding of ADAR-Mediated RNA Editing
This study is looking at how a protein called ADAR1 helps control the immune system's response to certain types of RNA that can cause autoimmune diseases, with the hope of finding new treatments that could help people with these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11074119 on NIH RePORTER |
What this research studies
This research investigates the role of the ADAR1 enzyme in regulating the body's innate immune response to double-stranded RNA (dsRNA), which can trigger autoimmune diseases. By exploring how ADAR1 edits RNA and interacts with immune pathways, the research aims to uncover mechanisms that prevent the immune system from mistakenly attacking the body's own cells. The study involves both laboratory experiments and analysis of immune responses, focusing on the differences between ADAR1's activities in the cytoplasm and nucleus. Patients may benefit from insights that could lead to new treatments for autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates are individuals with autoimmune diseases or conditions related to immune system dysregulation.
Not a fit: Patients with non-autoimmune conditions or those not affected by immune system issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases.
How similar studies have performed: Previous research has shown promise in understanding RNA editing and its implications for immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Li, Jin Billy — Stanford University
- Study coordinator: Li, Jin Billy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.