Understanding how acute kidney injury leads to chronic kidney disease
Tubuloglomerular feedback response in AKI to CKD transition
This study is looking at how a certain protein in the kidneys might help prevent kidney problems from getting worse after an injury, and it’s especially for people who have had acute kidney injury (AKI) and want to learn about new ways to protect their kidney health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11113929 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which acute kidney injury (AKI) can lead to chronic kidney disease (CKD). It focuses on the role of a specific protein, NOS1β, in regulating kidney function and how its decrease may contribute to the worsening of kidney health. By studying the response of kidney cells to injury, the research aims to identify potential new therapies that could prevent the transition from AKI to CKD. Patients with a history of AKI may be particularly relevant to this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced acute kidney injury and are at risk of developing chronic kidney disease.
Not a fit: Patients who have not experienced acute kidney injury or who already have advanced chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression from acute kidney injury to chronic kidney disease, improving long-term kidney health for many patients.
How similar studies have performed: Previous studies have shown promising results in understanding kidney injury mechanisms, but this specific approach to preventing AKI to CKD transition is relatively novel.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Liu, Ruisheng — University of South Florida
- Study coordinator: Liu, Ruisheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.