Understanding how actin influences brain cell connections
Actin Cytoskeleton in Postsynaptic Structure and Function
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11101378
This study looks at how a protein called actin helps shape the connections between brain cells, which are important for learning and memory, and it could help us understand brain disorders that affect these connections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11101378 on ClinicalTrials.gov |
What this research studies
This research investigates the role of actin, a key protein in cell structure, in the formation and function of synapses in the brain. By examining how actin dynamics affect the structure of dendritic spines, which are crucial for neurotransmitter signaling, the study aims to uncover the cellular mechanisms that support learning and memory. The approach involves advanced biochemical techniques to analyze the behavior of actin in relation to synaptic modifications. Patients may benefit from insights gained into brain disorders linked to synaptic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that affect synaptic function, such as Alzheimer's disease or other cognitive impairments.
Not a fit: Patients with purely structural brain abnormalities unrelated to synaptic function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for brain disorders by enhancing our understanding of synaptic function and plasticity.
How similar studies have performed: Other research has shown promising results in understanding synaptic mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHENG, JAMES Q — EMORY UNIVERSITY
- Study coordinator: ZHENG, JAMES Q
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders