Understanding how abnormal tau proteins affect brain function in Alzheimer's disease
Official title: Aberrant proteomes in tauopathy: revealing functional consequences via multimodal proteomics
Funded at University of California, San Francisco · NIH-11111785 · Data updated 2026-11-12
This study is looking at how unusual tau proteins might cause problems in the brain for people with Alzheimer's and frontotemporal dementia, using special lab techniques to understand how these proteins affect brain cells, with the hope of finding new treatments for those who are affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $816,661 |
| NIH project number | 1R01AG092454-01 |
| Project ID | NIH-11111785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or frontotemporal dementia, particularly those with tau pathology.
✕Less likely to help
Patients with neurodegenerative diseases not associated with tau pathology may not benefit from this research.
What this research studies
This research investigates the role of abnormal tau proteins in neurodegenerative diseases like Alzheimer's disease and frontotemporal dementia. By using advanced techniques in mass spectrometry-based proteomics and functional genomics, the study aims to map how tau pathology disrupts cellular processes and contributes to neuronal loss. The research will utilize both animal models and human-derived cells to gain insights into the molecular mechanisms at play, potentially leading to new therapeutic strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target tau pathology, improving outcomes for patients with Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in targeting tau pathology, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Swaney, Danielle L — University of California, San Francisco
- Study coordinator: Swaney, Danielle L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.