Understanding how ABCB7 affects blood cell production during emergencies
Official title: Cell-extrinsic emergency myelopoiesis regulated by ABCB7
Funded at Mayo Clinic Rochester · NIH-10884338 · Data updated 2026-11-12
This study is looking at how a protein called ABCB7 affects the way your body makes blood cells, especially when you're dealing with stress or inflammation, and it could help us understand blood-related conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $316,344 |
| NIH project number | 5R01HL167354-02 |
| Project ID | NIH-10884338 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammation or autoimmune diseases that may affect blood cell production.
✕Less likely to help
Patients without chronic inflammation or autoimmune conditions may not benefit from this research.
What this research studies
This research investigates the role of the ABCB7 protein in the production of blood cells, particularly during situations of stress or inflammation. It focuses on how the absence of ABCB7 in B cells affects the development of these cells in the bone marrow and leads to changes in blood cell production. By studying engineered mice that lack ABCB7, researchers aim to uncover the mechanisms behind emergency myelopoiesis, which is the body's response to increased demand for blood cells during chronic inflammation or autoimmune diseases. The findings could provide insights into conditions like myelodysplastic syndromes and improve our understanding of blood cell development.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with blood disorders related to inflammation and autoimmune diseases.
How similar studies have gone: Other research has shown promising results in understanding blood cell production mechanisms, but this specific approach focusing on ABCB7 is relatively novel.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Shapiro, Virginia Smith — Mayo Clinic Rochester
- Study coordinator: Shapiro, Virginia Smith
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.