Understanding how ABCB7 affects blood cell production during emergencies
Cell-extrinsic emergency myelopoiesis regulated by ABCB7
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10884338
This study is looking at how a protein called ABCB7 affects the way your body makes blood cells, especially when you're dealing with stress or inflammation, and it could help us understand blood-related conditions better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10884338 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the ABCB7 protein in the production of blood cells, particularly during situations of stress or inflammation. It focuses on how the absence of ABCB7 in B cells affects the development of these cells in the bone marrow and leads to changes in blood cell production. By studying engineered mice that lack ABCB7, researchers aim to uncover the mechanisms behind emergency myelopoiesis, which is the body's response to increased demand for blood cells during chronic inflammation or autoimmune diseases. The findings could provide insights into conditions like myelodysplastic syndromes and improve our understanding of blood cell development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammation or autoimmune diseases that may affect blood cell production.
Not a fit: Patients without chronic inflammation or autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with blood disorders related to inflammation and autoimmune diseases.
How similar studies have performed: Other research has shown promising results in understanding blood cell production mechanisms, but this specific approach focusing on ABCB7 is relatively novel.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAPIRO, VIRGINIA SMITH — MAYO CLINIC ROCHESTER
- Study coordinator: SHAPIRO, VIRGINIA SMITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases