Understanding how a specific receptor on lymphatic cells affects immune responses to influenza.
Official title: The Role of Lymphatic Endothelial Cell- Expressed Sphingosine-1-Phosphate Receptor 1 on Immune Cell Trafficking and Response to Influenza Virus
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10997982 · Data updated 2026-11-12
This study is looking at how a specific protein on lymphatic cells helps control the movement and activity of immune cells during an influenza infection, which could lead to better ways to boost our immune response when we're sick.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 3, 2024 |
| Project end | September 2, 2028 |
| Funding year | 2024 |
| Award (this year) | $46,051 |
| NIH project number | 1F30HL176087-01 |
| Project ID | NIH-10997982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting their immune response, particularly those with autoimmune diseases or lymphatic dysfunction.
✕Less likely to help
Patients with no immune response issues or those not affected by viral infections may not benefit from this research.
What this research studies
This research investigates the role of sphingosine-1-phosphate receptor 1 (S1PR1) expressed on lymphatic endothelial cells in regulating immune cell movement and response to influenza virus. By studying how these cells transport immune cells to lymph nodes and influence their activation, the research aims to uncover mechanisms that could enhance immune responses. The approach includes examining changes in immune cell behavior in genetically modified mice lacking S1PR1 on lymphatic cells. This could provide insights into how lymphatic dysfunction impacts the body's ability to fight infections.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses against viral infections like influenza.
How similar studies have gone: Previous research has shown that targeting lymphatic endothelial cell functions can influence immune responses, indicating potential for success in this approach.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Labombarde, Jocelyn — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Labombarde, Jocelyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.