Understanding how a specific protein protects against lung injury
Protective role of Endothelial Receptor Interacting Protein Kinase 3 (RIPK3) in acute lung injury
This study is looking at how a protein called RIPK3 helps protect the lungs during serious inflammation, like what happens in acute respiratory distress syndrome (ARDS), using mice and lab-grown lung cells to find ways to better treat patients with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11018624 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called RIPK3 in protecting the lungs during acute lung injury, particularly in conditions characterized by inflammation. The study will utilize mouse models and human organoid systems to explore how inflammation affects lung cells and how RIPK3 can mitigate damage. By identifying biomarkers related to vascular injury and cell death, the research aims to enhance our understanding of acute respiratory distress syndrome (ARDS) and improve treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing acute lung injury or conditions related to acute respiratory distress syndrome.
Not a fit: Patients with chronic lung diseases or those not experiencing acute lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for patients suffering from acute lung injuries, potentially improving survival and recovery rates.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of lung injury and the role of inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Price, David Regan — Weill Medical Coll of Cornell Univ
- Study coordinator: Price, David Regan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.