Understanding how a specific protein modification affects pneumonia after viral infections
Official title: The vital role of T403 phosphorylation of STAT2 in post-viral bacterial pneumonia
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11057677 · Data updated 2026-11-12
This study is looking at how a change in a protein called STAT2 affects the body's ability to fight off bacterial infections that can happen after a viral illness, like the flu, to help find better treatments for people who get sick from these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | March 20, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $507,150 |
| NIH project number | 5R01HL166544-02 |
| Project ID | NIH-11057677 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have experienced viral infections and are at risk of developing post-viral bacterial pneumonia.
✕Less likely to help
Patients who have not had a recent viral infection or those with chronic bacterial pneumonia may not benefit from this research.
What this research studies
This research investigates the role of a specific modification of the STAT2 protein in the body's response to infections that occur after a viral illness, particularly focusing on post-viral bacterial pneumonia. By examining how this modification affects the immune response, the study aims to identify key mechanisms that lead to increased susceptibility to bacterial infections following a viral infection. The research employs advanced techniques to analyze immune cell behavior and responses in the context of viral and bacterial co-infections, which could lead to new therapeutic strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from pneumonia following viral infections, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown promising results in understanding immune responses to viral and bacterial infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Wang, Yuxin — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Wang, Yuxin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.