Understanding how a specific protein modification affects pneumonia after viral infections
The vital role of T403 phosphorylation of STAT2 in post-viral bacterial pneumonia
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11057677
This study is looking at how a change in a protein called STAT2 affects the body's ability to fight off bacterial infections that can happen after a viral illness, like the flu, to help find better treatments for people who get sick from these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11057677 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific modification of the STAT2 protein in the body's response to infections that occur after a viral illness, particularly focusing on post-viral bacterial pneumonia. By examining how this modification affects the immune response, the study aims to identify key mechanisms that lead to increased susceptibility to bacterial infections following a viral infection. The research employs advanced techniques to analyze immune cell behavior and responses in the context of viral and bacterial co-infections, which could lead to new therapeutic strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced viral infections and are at risk of developing post-viral bacterial pneumonia.
Not a fit: Patients who have not had a recent viral infection or those with chronic bacterial pneumonia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from pneumonia following viral infections, potentially reducing mortality rates.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to viral and bacterial infections, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, YUXIN — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: WANG, YUXIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome