Understanding how a specific protein helps cells survive and function properly
Official title: Elucidating the Mechanistic Details of the Grp94 Molecular Chaperone through an Integrated Computational and Experimental Approach
Funded at Miami University Oxford · NIH-10876394 · Data updated 2026-11-12
This study is looking at a protein called Grp94 that helps other proteins fold correctly in our cells, which is important because when proteins don’t fold right, it can lead to serious health problems like diabetes and cancer, and the researchers hope their findings will help create better treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Miami University Oxford NIH-funded |
| Lab location | 1 site (Oxford, United States) |
| Project start | August 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $343,784 |
| NIH project number | 5R35GM146963-03 |
| Project ID | NIH-10876394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions related to protein misfolding, such as type 2 diabetes, certain cancers, or neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to protein misfolding or those who do not have any of the target diseases may not benefit from this research.
What this research studies
This research investigates the role of a protein called Grp94, which is essential for proper protein folding within cells. By using both computational and experimental methods, the team aims to uncover the mechanisms by which Grp94 operates, particularly in the endoplasmic reticulum. This understanding is crucial because misfolded proteins can lead to serious health issues, including diabetes, cancer, and neurodegenerative diseases. The findings could pave the way for new drug designs that target these diseases more effectively.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by protein misfolding, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in targeting similar chaperone proteins for therapeutic purposes, indicating a potential for success in this area.
Where this research is happening
-
Miami University Oxford
Oxford, United States Active
Researchers
- Principal investigator: Kravats, Andrea N — Miami University Oxford
- Study coordinator: Kravats, Andrea N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.