Understanding how a specific protein affects lipid transport and heart disease risk
Official title: Defining the role of PLA2G12B on apoB-containing lipoprotein assembly, plasma levels, metabolism and cardiovascular disease risk
Funded at Johns Hopkins University · NIH-11047433 · Data updated 2026-11-12
This study is looking at a protein called PLA2G12B to understand how it helps manage fats in the blood and how this might relate to heart disease, with the hope that what we learn could help people at risk for heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 15, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $603,632 |
| NIH project number | 1R01DK138195-01A1 |
| Project ID | NIH-11047433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with elevated lipid levels or a family history of cardiovascular disease.
✕Less likely to help
Patients who do not have issues related to lipid metabolism or cardiovascular disease may not receive benefit from this research.
What this research studies
This research investigates the role of a protein called PLA2G12B in the assembly and metabolism of lipoproteins that carry fats in the bloodstream. By studying how this protein interacts with other molecules involved in lipid transport, the research aims to uncover mechanisms that contribute to atherosclerotic cardiovascular disease (CVD). The approach includes using mouse models and cultured human cells to observe the effects of PLA2G12B deficiency on lipid levels and atherosclerosis. Patients may benefit from insights gained about lipid metabolism and heart disease risk factors.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for reducing cardiovascular disease risk by targeting lipid metabolism.
How similar studies have gone: Previous research has shown success in understanding lipid metabolism and its implications for cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Farber, Steven a — Johns Hopkins University
- Study coordinator: Farber, Steven a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.