Understanding how a specific protein affects immune responses during severe lung infections
Official title: Central role of Caspase-8 in control of host tolerance and resistance mechanisms in pulmonary macrophage populations during severe respiratory infections
Funded at Brown University · NIH-11179637 · Data updated 2026-11-12
This study is looking at how a protein called Caspase-8 helps our immune cells, called macrophages, fight off serious lung infections like pneumonia while also helping to heal any damage caused by the infection, with the goal of finding better ways to help patients recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $56,400 |
| NIH project number | 3R01HL165259-02S1 |
| Project ID | NIH-11179637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from severe respiratory infections, particularly those with pneumonia caused by influenza or bacterial pathogens.
✕Less likely to help
Patients with mild respiratory infections or those not experiencing significant immune response issues may not benefit from this research.
What this research studies
This research investigates the role of Caspase-8, a protein involved in cell death, in managing the immune response of macrophages during severe respiratory infections like pneumonia. The study aims to understand how this protein helps the body balance fighting off infections while also repairing tissue damage caused by the infection. By examining the interactions between viral and bacterial infections, the researchers hope to identify new strategies to improve patient outcomes. The approach includes analyzing immune responses in laboratory settings to uncover mechanisms that could be targeted for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to tolerate and recover from severe respiratory infections.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Jamieson, Amanda M — Brown University
- Study coordinator: Jamieson, Amanda M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.