Understanding how a specific protein affects immune cells in type 1 diabetes
Official title: Mechanisms by which PIM kinase modulates the effector function of autoreactive CD8 T cells in type 1 diabetes
Funded at Medical College of Wisconsin · NIH-11060012 · Data updated 2026-11-12
This study is looking at how a protein called PIM1 affects immune cells that mistakenly attack the insulin-producing cells in people with type 1 diabetes, with the hope of finding new ways to help manage or treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | April 7, 2023 |
| Project end | April 6, 2027 |
| Funding year | 2025 |
| Award (this year) | $54,538 |
| NIH project number | 5F30DK132807-03 |
| Project ID | NIH-11060012 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are experiencing challenges with insulin management.
✕Less likely to help
Patients with type 2 diabetes or other non-autoimmune related diabetes conditions may not benefit from this research.
What this research studies
This research investigates the role of PIM1, a protein kinase, in regulating the function of immune cells that attack insulin-producing cells in type 1 diabetes. By studying how PIM1 influences the behavior of autoreactive CD8 T cells, the research aims to uncover new therapeutic targets that could help manage or treat this autoimmune condition. The approach includes advanced techniques like single-cell RNA sequencing to analyze the molecular mechanisms at play. If successful, this research could lead to innovative treatments that improve the lives of those affected by type 1 diabetes.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies to better manage or potentially reverse type 1 diabetes.
How similar studies have gone: Other research has shown promise in targeting immune cell functions in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Brown, Ashley K — Medical College of Wisconsin
- Study coordinator: Brown, Ashley K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.