Understanding how a specific protein affects immune cells in type 1 diabetes
Mechanisms by which PIM kinase modulates the effector function of autoreactive CD8 T cells in type 1 diabetes
This study is looking at how a protein called PIM1 affects immune cells that mistakenly attack the insulin-producing cells in people with type 1 diabetes, with the hope of finding new ways to help manage or treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11060012 on NIH RePORTER |
What this research studies
This research investigates the role of PIM1, a protein kinase, in regulating the function of immune cells that attack insulin-producing cells in type 1 diabetes. By studying how PIM1 influences the behavior of autoreactive CD8 T cells, the research aims to uncover new therapeutic targets that could help manage or treat this autoimmune condition. The approach includes advanced techniques like single-cell RNA sequencing to analyze the molecular mechanisms at play. If successful, this research could lead to innovative treatments that improve the lives of those affected by type 1 diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are experiencing challenges with insulin management.
Not a fit: Patients with type 2 diabetes or other non-autoimmune related diabetes conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies to better manage or potentially reverse type 1 diabetes.
How similar studies have performed: Other research has shown promise in targeting immune cell functions in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Brown, Ashley K — Medical College of Wisconsin
- Study coordinator: Brown, Ashley K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.