Understanding how a specific protein affects immune cells in the colon
Official title: Define the role of REV-ERB in colonic RORgt+ regulatory T cells
Funded at Salk Institute for Biological Studies · NIH-10886106 · Data updated 2026-11-12
This study is looking at how a protein called REV-ERB affects a type of immune cell that helps keep our immune system balanced and prevents autoimmune diseases, especially in the colon, which could lead to new ways to treat immune-related conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | July 11, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $237,500 |
| NIH project number | 5R21AI178938-02 |
| Project ID | NIH-10886106 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or conditions characterized by immune dysregulation.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by immune system imbalances may not benefit from this research.
What this research studies
This research investigates the role of a protein called REV-ERB in a special type of immune cell known as RORgt+ regulatory T cells, which are important for maintaining immune balance and preventing autoimmune diseases. The study focuses on how these cells function in the colon and how REV-ERB influences their ability to suppress inflammation. By using advanced techniques like RNA sequencing and specific assays, researchers aim to uncover the mechanisms behind the regulation of these immune cells. This could lead to new insights into treating conditions related to immune dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for autoimmune diseases by enhancing the function of regulatory T cells.
How similar studies have gone: Previous research has shown promising results in understanding immune cell regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Zheng, Ye — Salk Institute for Biological Studies
- Study coordinator: Zheng, Ye
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.