Understanding how a specific protein affects eye growth and vision errors
Characterizing the Molecular Mechanisms of PRSS56-Dependent Ocular Growth and Refractive Error
This study is looking at how certain proteins, especially one called PRSS56, affect eye growth and can lead to vision issues like myopia, so that people with these conditions can better understand what’s happening with their eyes and potentially find new ways to improve their vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11101057 on NIH RePORTER |
What this research studies
This research investigates the molecular and genetic factors that control eye growth and the development of refractive errors like myopia, which can lead to vision loss. By focusing on a protein called PRSS56, the study aims to uncover how it influences the growth of the eye during both prenatal and postnatal stages. The researchers will explore the signaling processes between the retina and the sclera that contribute to proper eye development and how disruptions in these processes can lead to conditions like myopia. Patients may benefit from insights gained about the underlying mechanisms of their vision problems.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing myopia or other refractive errors, particularly those with a family history of these conditions.
Not a fit: Patients with refractive errors unrelated to genetic factors or those who have already undergone corrective surgeries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating refractive errors and associated vision loss.
How similar studies have performed: Previous research has shown promising results in understanding the genetic and molecular mechanisms of eye growth, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Nair, Kayarat Saidas — University of California, San Francisco
- Study coordinator: Nair, Kayarat Saidas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.