Understanding how a specific protein affects eye growth and vision errors
Official title: Characterizing the Molecular Mechanisms of PRSS56-Dependent Ocular Growth and Refractive Error
Funded at University of California, San Francisco · NIH-10880614 · Data updated 2026-11-12
This study is looking at how a protein called PRSS56 affects eye growth and vision problems like myopia, with the hope of finding new ways to help people with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $389,892 |
| NIH project number | 5R01EY032666-03 |
| Project ID | NIH-10880614 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing refractive errors, particularly those with myopia or related vision issues.
✕Less likely to help
Patients with refractive errors not related to the mechanisms being studied, or those with other unrelated ocular conditions, may not benefit from this research.
What this research studies
This research investigates the molecular and genetic mechanisms that regulate eye growth and refractive errors, particularly focusing on a protein called PRSS56. By studying how this protein influences the growth of the eye during both prenatal and postnatal development, the research aims to uncover the processes that lead to conditions like myopia. The approach involves examining the signals between the retina and the sclera that contribute to proper eye development and refractive accuracy. Patients may benefit from insights that could lead to new treatments for vision problems caused by improper eye growth.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating refractive errors like myopia, potentially reducing the risk of vision loss.
How similar studies have gone: Previous research has shown promise in understanding the genetic factors influencing eye growth, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Nair, Kayarat Saidas — University of California, San Francisco
- Study coordinator: Nair, Kayarat Saidas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.