Understanding how a specific protein affects brain tumors
Official title: Investigating the role of CARM1-mediated methylation of Qki in glioblastoma
Funded at University of Tx Md Anderson Can Ctr · NIH-11070737 · Data updated 2026-11-12
This study is looking at a protein called Qki to see how it affects glioblastoma stem cells, which are important for the growth and treatment resistance of this aggressive brain tumor, with the hope of finding new ways to help patients get better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $37,598 |
| NIH project number | 1F31CA298677-01 |
| Project ID | NIH-11070737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with glioblastoma, particularly those with specific genetic mutations affecting the Qki protein.
✕Less likely to help
Patients with other types of brain tumors or those whose glioblastoma does not involve Qki dysregulation may not benefit from this research.
What this research studies
This research investigates the role of a protein called Qki in glioblastoma, the most aggressive type of brain tumor. It focuses on how changes in Qki can influence the behavior of glioblastoma stem cells, which are crucial for tumor growth and resistance to treatment. By studying the mechanisms behind Qki's function and its interactions with other proteins, the research aims to uncover new therapeutic strategies for glioblastoma. Patients may benefit from insights that could lead to more effective treatments targeting these tumor cells.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target glioblastoma stem cells, potentially improving outcomes for patients.
How similar studies have gone: Previous research has shown promising results in targeting similar molecular mechanisms in glioblastoma, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Lu, Kaylene Jiayi — University of Tx Md Anderson Can Ctr
- Study coordinator: Lu, Kaylene Jiayi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.