Understanding how a specific protein affects alcohol sensitivity.
Identification of the protein:protein interactions of a non-nuclear NFKB that modulates ethanol sensitivity.
['FUNDING_R21'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-10825577
This study is looking at a protein called DifB to see how it affects the brain's response to alcohol, which could help us understand alcohol use disorders better and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-10825577 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called DifB, which is involved in how the brain responds to alcohol. By studying this protein's interactions in the brain, researchers aim to uncover how it influences sensitivity to ethanol, which is the active ingredient in alcoholic beverages. The study uses advanced techniques to analyze how DifB operates at synapses, the connections between neurons, rather than just in the nucleus of cells. This could lead to new insights into alcohol use disorders and potential treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who may be experiencing issues related to alcohol use or sensitivity.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for individuals struggling with alcohol use disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuroimmune signaling in alcohol sensitivity, suggesting that this approach could yield valuable insights.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ATKINSON, NIGEL S — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: ATKINSON, NIGEL S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: ethanol use disorder, alcohol use disorder