Understanding how a specific immune cell receptor affects allergic asthma
Study the role of ICOS on murine and human ILC2s
This study is looking at how a specific immune cell receptor affects allergy-related immune cells in asthma, with the hope of finding new ways to help people with asthma breathe easier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11045291 on NIH RePORTER |
What this research studies
This research investigates the role of the ICOS receptor on a type of immune cell called ILC2s, which are known to contribute to allergic asthma. By studying both mouse models and human samples, the researchers aim to understand how ICOS influences the behavior of these cells and their production of inflammatory substances. The goal is to identify ways to reprogram these immune cells to reduce airway hyperreactivity, a key feature of asthma. Patients may benefit from insights that could lead to new treatments targeting these immune mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from allergic asthma or related airway hyperreactivity conditions.
Not a fit: Patients with non-allergic asthma or those whose asthma is not influenced by immune mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better control allergic asthma and improve patient quality of life.
How similar studies have performed: Previous studies have shown promising results in manipulating immune cell functions to treat asthma, suggesting that this approach could be effective.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Akbari, Omid — University of Southern California
- Study coordinator: Akbari, Omid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.