Understanding how a specific genetic region affects aging and related diseases
Comprehensive functional genomic analysis of the multi-disease associated CDKN2A/B locus
This study is looking at certain genes that might affect your risk for age-related diseases like heart problems and Type 2 diabetes, so we can better understand how they influence aging and help improve prevention and treatment for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10874473 on NIH RePORTER |
What this research studies
This research investigates the CDKN2A/B genetic locus, which has been linked to various age-related diseases such as cardiovascular disease and Type 2 diabetes. By utilizing advanced techniques like high throughput sequencing, the study aims to identify which genes within this locus contribute to these conditions and how they may influence aging. Patients may benefit from insights gained about the genetic factors that predispose them to these diseases, potentially leading to improved prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for age-related diseases, particularly those with a family history of cardiovascular disease, diabetes, or cancer.
Not a fit: Patients who are not at risk for age-related diseases or do not have a family history of these conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of age-related diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding genetic contributions to age-related diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Li, Gang — University of Pittsburgh at Pittsburgh
- Study coordinator: Li, Gang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.