Understanding how a specific gene controls development in embryos
Official title: Control of precisely timed gene expression during notochord development by Brachyury
Funded at New York University · NIH-11132846 · Data updated 2026-11-12
This study is looking at how a specific gene called Brachyury helps control when other genes turn on during the early development of a key structure in embryos, which could help us understand how babies develop and why some might have birth defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 5, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $322,000 |
| NIH project number | 5R01GM149841-02 |
| Project ID | NIH-11132846 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of birth defects or developmental disorders related to notochord development.
✕Less likely to help
Patients with conditions unrelated to genetic regulation of development or those who are not affected by birth defects may not benefit from this research.
What this research studies
This research investigates the role of the Brachyury gene in regulating the timing of gene expression during the development of the notochord, a crucial structure in all chordate embryos. By studying the mechanisms that govern when and how genes are activated, the research aims to uncover the genetic and molecular processes that ensure proper embryonic development. The approach involves examining the expression patterns of Brachyury and its downstream genes in the model organism Ciona, which shares developmental features with humans. This could provide insights into the fundamental processes of development and potential causes of birth defects.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental disorders and potential strategies for preventing birth defects.
How similar studies have gone: Other research has shown success in understanding gene regulation in development, making this approach promising and relevant.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Di Gregorio, Anna — New York University
- Study coordinator: Di Gregorio, Anna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.