Understanding how a specific gene controls development in embryos
Control of precisely timed gene expression during notochord development by Brachyury
This study is looking at how a specific gene called Brachyury helps control when other genes turn on during the early development of a key structure in embryos, which could help us understand how babies develop and why some might have birth defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11132846 on NIH RePORTER |
What this research studies
This research investigates the role of the Brachyury gene in regulating the timing of gene expression during the development of the notochord, a crucial structure in all chordate embryos. By studying the mechanisms that govern when and how genes are activated, the research aims to uncover the genetic and molecular processes that ensure proper embryonic development. The approach involves examining the expression patterns of Brachyury and its downstream genes in the model organism Ciona, which shares developmental features with humans. This could provide insights into the fundamental processes of development and potential causes of birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of birth defects or developmental disorders related to notochord development.
Not a fit: Patients with conditions unrelated to genetic regulation of development or those who are not affected by birth defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental disorders and potential strategies for preventing birth defects.
How similar studies have performed: Other research has shown success in understanding gene regulation in development, making this approach promising and relevant.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Di Gregorio, Anna — New York University
- Study coordinator: Di Gregorio, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.