Understanding how a specific gene affects tooth enamel development
Official title: Deciphering the role of MEMO1 during amelogenesis
Funded at University of Iowa · NIH-11068217 · Data updated 2026-11-12
This study is looking at how a gene called MEMO1 affects tooth enamel development, especially for people with amelogenesis imperfecta, a condition that causes weak enamel, to help find better treatments for enamel problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $37,973 |
| NIH project number | 1F31DE034609-01 |
| Project ID | NIH-11068217 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adults diagnosed with amelogenesis imperfecta or those experiencing enamel defects.
✕Less likely to help
Patients without enamel disorders or those not affected by genetic conditions related to enamel development may not benefit from this research.
What this research studies
This research investigates the role of the MEMO1 gene in the development of tooth enamel, particularly in individuals with amelogenesis imperfecta (AI), a genetic condition that leads to weak and damaged enamel. By studying how MEMO1 functions in ameloblasts, the cells responsible for enamel formation, the research aims to uncover the molecular mechanisms behind normal and abnormal enamel development. The project will utilize advanced techniques to observe the behavior of MEMO1 during the critical stages of enamel mineralization, which could lead to new insights into potential treatments or regenerative therapies for enamel defects.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with amelogenesis imperfecta, enhancing their dental health and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors affecting enamel development, but the specific role of MEMO1 in amelogenesis is still being explored.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Wuebker, Samantha — University of Iowa
- Study coordinator: Wuebker, Samantha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.